While I don't like to hack Drupal core, there are a few tweaks to Drupal that I've found myself making to enhance the ability to administrate that I'm not able to accomplish using hooks.
Because each module on the module configuration page lists all of its dependencies and all of the modules dependent on it, it is often hard to find the checkbox for a given module on the module. This quick fix will put a carat (^) in front of each module name so you can quickly search for the checkbox to enable/disable or configure it: